Wound Healing Potential of Calligonum Comosum in the Rat Model: Morphological and Histopathological Evidences

Calligonum comosum Family Polygonaceae is a perennial shrub that grows in the desert areas Saudi Arabia. The plant extensively used for economic purposes and traditional medicine. tanning hides wound. current study aims to provide scientific evidence wound healing potential. was extracted with methanol at room temperature water by decoction against two Gram-positive bacterial strains; Bacillus subtilis Staphylococcus aureus, Gram-negative strains, Escherichia coli Klebsiella pneumonia, addition pathogenic fungus Candida albicans. extract were formulated as creams applied evaluate potential using rats experimental animals. more active antimicrobial testing accelerating of wounds than extract. Wound accessed via morphological parameters such contraction, epithelization period detailed well histopathological healed skin. completely control group treated Fucidin 2% cream after 18 days, while reached 96.6% contraction same period. much less gays resulted only 73.2% contraction. Skin samples showed improvement almost normal appearance content collagen fibers, although slight weakness near epidermis layer observed. obtained results strongly document beneficial effects C. activator reveal best method extraction plant.